Boğaziçi CT3
Hizmetler
Device Name / Brand / Model
• Name: LC-MS/MS (Liquid Chromatography – Tandem Mass Spectrometry)
• Brand: Shimadzu
• Model: 8050
Overview
LC-MS/MS is a highly selective and sensitive analytical technique that combines the high separation capability of liquid chromatography with the precise detection power of mass spectrometry. The mass spectrometer (MS) ionizes sample components, separates them according to their mass-to-charge ratios (m/z), and measures ion intensities, enabling both qualitative identification and quantitative determination. Our LC-MS/MS systems are primarily used for drug, medical device, and bioanalytical research applications. The platform is also widely applicable in areas such as food safety, environmental contaminant analysis, and forensic toxicology.
Purpose / Output
• Highly selective qualitative identification of target compounds in complex matrices
• High-sensitivity quantitative determination in biological matrices (plasma, serum, urine, etc.)
• Monitoring of active ingredients, impurities, metabolites, and degradation products
• Bioanalytical measurements for biomarkers, PK/PD studies, and in vivo tracking applications
Application Areas
• Drug and pharmaceutical analyses
– Active ingredient, impurity, and metabolite analyses
– Quantitative drug level determination in biological matrices for BA/BE studies
– Stability testing and monitoring of degradation products (degradants)
• Bioanalytical applications
– Biomarker determination in clinical samples
– Pharmacokinetic and pharmacodynamic studies
– In vivo monitoring of drug delivery systems for targeted therapies
• Medical device–related analyses
– Detection of extractables/leachables from materials used in manufacturing
– Residue analysis in sample matrices within biocompatibility studies
• Additional applications
– Food safety
– Environmental contaminant analysis
– Forensic toxicology
Highlights
• Broad mass range (m/z 2–2000) enabling versatile analytical coverage
• High throughput supported by fast scanning and rapid polarity switching
• Strong signal-to-noise performance suitable for trace-level quantitation
Technical Specifications
| Feature | Value / Description |
|---|---|
| Scan speed | 15,000 u/s |
| Polarity switching time | 15 ms |
| S/N | 1 pg Reserpine: S/N 50,000; 1 pg Chloramphenicol: S/N 50,000 |
| Dwell time | 0.8 ms |
| Mass range | m/z 2–2000 |
| Mass accuracy | m/z 1000 ±0.15 (0.015%) |
| Mass stability | 0.05 u / 12 h |
Contact / Service Request
For service requests: you may email [email protected]. (Please specify the sample type, purpose, and preferred date range.)