Device Name / Brand / Model
• Name: GPC/SEC Multi-Detector Suite (Gel Permeation Chromatography / Size-Exclusion Chromatography)
• Brand: Agilent
• Model: 1260 Infinity GPC/SEC Multi-Detector Suite (MDS)

Overview
Gel Permeation Chromatography (GPC) is a size-exclusion chromatography (SEC) technique that separates analytes in organic solvents based on their molecular size. It is widely used to determine the molecular weight distribution of polymers and other high-molecular-weight compounds. Polymer systems are typically characterized by number-average molecular weight (Mn), weight-average molecular weight (Mw), z-average molecular weight (Mz), and viscosity-average molecular weight (Mv). GPC also provides critical structural information such as dispersity (the breadth of the molecular weight distribution).

The Agilent 1260 Infinity GPC/SEC Multi-Detector Suite (MDS) used at our center is an advanced four-detector system. With RI, viscometer, dual-angle static light scattering (Dual Angle LS) and dynamic light scattering (DLS) detectors, it enables acquisition of complex structural information such as absolute molecular weight, hydrodynamic diameter, and solution behavior.

Purpose / Output
• Determination of molecular weight distribution for polymers and high-molecular-weight compounds
• Calculation of Mn, Mw, Mz, Mv, and dispersity (Ð)
• Advanced characterization and absolute molecular weight determination using multi-detection
• Additional outputs such as hydrodynamic diameter and solution behavior metrics

Application Areas
• Biotherapeutics (e.g., monoclonal antibodies, protein therapies): monomer/dimer/aggregate analysis
• Detailed molecular weight distribution characterization of polymer-based drug delivery systems (micro-/nanoparticles, hydrogels, etc.)
• Analysis of polymer properties affecting formulation in next-generation targeted drugs (Mv, Mw, Mn, dispersity)
• Determination of structural parameters influencing biocompatibility and controlled release in drug delivery systems

Highlights
• 4-detector MDS configuration: RI + Viscometer + Dual Angle LS + DLS
• Access to advanced structural outputs such as absolute molecular weight and hydrodynamic diameter
• High repeatability enabled by independent detector temperature control

Technical Specifications

Feature	Value / Description
System	Agilent 1260 Infinity GPC/SEC Multi-Detector Suite (MDS)
Detectors	RI, Viscometer, Dual Angle Light Scattering, Dynamic Light Scattering
Detector temperature control	Independent 30–60 °C for each detector
pH range	2 – 10
Light scattering flow cell	Low volume 10 µL
Scattering angles	15° – 90°
RI cell	6 µL high-pressure RI cell (minimal dispersion)
Usage note	In operation

Contact / Service Request
For service requests: you may email [email protected]. (Please specify the sample type, purpose, and preferred date range.)